Allogeneic tumor cell-derived extracellular vesicles stimulate CD8 T cell response in colorectal cancer
Most colorectal cancer (CRC) patients present with a microsatellite-stable phenotype, rendering them resistant to immune checkpoint Microwave Leakage Detector inhibitors (ICIs).Among the contributors to ICI resistance, tumor-derived extracellular vesicles (TEVs) have emerged as critical players.Previously we demonstrated that autologous transfer of